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Webster 1913 Edition

Verb.

[

imp. & p. p.

Unsexed

;

p. pr. & vb. n.

Unsexing

[1st pref.

un-

sex

To deprive of sex, or of qualities becoming to one’s sex; esp., to make unfeminine in character, manners, duties, or the like;

as, to

unsex

a woman

Verb.

To deprive of the sex, or to make otherwise than the sex commonly is.

unsex ‎(third-person singular simple present unsexes, present participle unsexing, simple past and past participle unsexed)

To deprive of sexual attributes or characteristics.
- 1603-06, William Shakespeare, Macbeth, Act I, Scene V:
  Lady Macbeth: "Come, you spirits / That tend on mortal thoughts! unsex me here, / And fill me from the crown to the toe full / Of direst cruelty:"
To sterilize (deprive of the ability to procreate); to castrate.